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TLS Online TPP Program

#Id: 9316

Light absorption by rhodopsin→activation of a cGMP PDE → hydrolyzes cGMP to 5′-GMP→ cGMP levels  drop →channel close →membrane hyperpolarization→reduction in NT release→transmitted to brain

#XL - T Zoology #Visual Signaling #Part B Pointers
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TLS Online TPP Program

#Id: 9053

#XL - T Zoology

Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; i.e., binding of the first cAMP molecule to CNB-B lowers the Kd for binding of the second cAMP to CNB-A.
TLS Online TPP Program

#Id: 9054

#XL - T Zoology

The activated β2-adrenergic receptor induces GDP-->GTP exchange on a stimulatory G protein (Gs).
TLS Online TPP Program

#Id: 9055

#XL - T Zoology
TLS Online TPP Program

#Id: 9056

#XL - T Zoology
TLS Online TPP Program

#Id: 9057

#XL - T Zoology

glutamate (E200) and arginine (R209) participate in binding of cAMP, which causes a conformational change in the loop that prevents binding of the loop to the C subunit.
TLS Online TPP Program

#Id: 9058

#XL - T Zoology

Epinephrine --> Gαs-GTP-->Adenylyl cyclase-->cAMP-->PKA