Smad2/3 become phosphorylated by active RI receptors and together with Smad4 move into the nucleus to activate gene transcription

TLS Online TPP Program

#Id: 9718

#XL - T Zoology

Fus3 translocates into the nucleus & phosphorylates two proteins, Dig1 and Dig2.

TLS Online TPP Program

#Id: 9719

#XL - T Zoology

Phosphorylated Dig1 and Dig2, relieves the inhibition of the Ste12 transcription factor.

TLS Online TPP Program

#Id: 9720

#XL - T Zoology

Activated Ste12, induces expression of proteins

involved in mating-specific cellular responses.

TLS Online TPP Program

#Id: 9956

#XL - T Zoology

Human genome encodes 19 different Wnt proteins, and essential for critical developmental events, including:

Brain development

Limb patterning

Organogenesis

Formation of osteoblasts

TLS Online TPP Program

#Id: 9957

#XL - T Zoology

Wnts are paracrine factors that make up a large family of cysteine-rich glycoproteins

TLS Online TPP Program

#Id: 9958

#XL - T Zoology

Structure of Wnt proteins 

22 cysteine residues, which form disulfide bridges that maintain a globular secondary structure.