TLS Online TPP Program

#Id: 8639

#XL - T Zoology

Phosphorylation of Whi5 promotes its export out of the nucleus, allowing the transcription factor complex SBF to induce transcription of the G1/S phase cyclin genes CLN1 and CLN2.

TLS Online TPP Program

#Id: 8640

#XL - T Zoology

In vertebrates, Rb is the major guardian of the cell cycle, integrating information about DNA damage and cell growth

TLS Online TPP Program

#Id: 8641

#XL - T Zoology

Rb binds the activation domains of a E2F transcription factors, in the cytoplasm to prevent them from turning on the genes required for cell cycle progression.

TLS Online TPP Program

#Id: 8642

#XL - T Zoology

TLS Online TPP Program

#Id: 8643

#XL - T Zoology

When E2Fs are bound to Rb, not only are they transcriptionally inactive, but they also function to repress transcription by recruiting chromatin-modifying enzymes that promote deacetylation and methylation of specific histone lysines.

TLS Online TPP Program

#Id: 8644

#XL - T Zoology

Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.