Web making in spiders

Spiders make silk in a special part of their body called a gland and use their legs to pull it out of their bodies. This is called spinning.

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Main action of the PKB signaling pathway

An increase in uptake of glucose from the blood within minutes.

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Fat and muscle cells express large amounts of the insulin-responsive glucose transporter GLUT4

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In resting cells, the majority of the GLUT4 protein is

localized to specialized GLUT4 storage vesicles (GSVs)

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GSVs tethered to the Golgi matrix, by a protein termed TUG (Tether containing a UBX domain for GLUT4).

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Binding of insulin to its receptor triggers activation of a protease that catalyzes a site-specific endoproteolytic cleavage of TUG

TLS Online TPP Program

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Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.