The extracellular domain of cytokine receptors are constructed of two subdomains, each contains seven conserved β strands folded together

TLS Online TPP Program

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#XL - T Zoology

TLS Online TPP Program

#Id: 8643

#XL - T Zoology

When E2Fs are bound to Rb, not only are they transcriptionally inactive, but they also function to repress transcription by recruiting chromatin-modifying enzymes that promote deacetylation and methylation of specific histone lysines.

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Phosphorylation on multiple sites by G1 CDKs blocks Rb from associating with E2F and promotes its export out of the nucleus.

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Rb protein regulation by G1 CDKs in mammalian cells is analogous to Whi5 regulation by Cln3-CDK in yeast.

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One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

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#Id: 8647

#XL - T Zoology