All STAT proteins contain: 

an N-terminal DNA-binding domain

an SH2 domain

a C-terminal domain with a critical tyrosine residue

TLS Online TPP Program

#Id: 1349

#XL - T Zoology

RAF (also known as MAPKKK),  A ser/thr protein kinase

TLS Online TPP Program

#Id: 1350

#XL - T Zoology

KSR (Kinase suppressor of Ras) is a pseudogene homolog of RAF Involve in the activation of RAF

TLS Online TPP Program

#Id: 1351

#XL - T Zoology

CNK serves as a molecular scaffold platform for KSR-mediated RAF activation

 

TLS Online TPP Program

#Id: 1352

#XL - T Zoology

GRB2 SH3 domains bind to proline-rich sequences in Sos

  

TLS Online TPP Program

#Id: 1353

#XL - T Zoology

GRB2 SH2 domain binds to a specific phosphotyrosine residue in the cytosolic domain of an activated RTK.

 

TLS Online TPP Program

#Id: 1354

#XL - T Zoology

The SH2 domain binds strongly to any peptide containing a critical four-residue core sequence:  phosphotyrosine–glutamic acid–glutamic acid–isoleucine