SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.

TLS Online TPP Program

#Id: 8849

#XL - T Zoology

Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

TLS Online TPP Program

#Id: 8850

#XL - T Zoology

Geminin 

a small protein,, that contributes to the inhibition of re-initiation at origins until cells complete a full cell cycle.

TLS Online TPP Program

#Id: 8851

#XL - T Zoology

Geminin is expressed in late G1; it binds to and inhibits Cdt1 preventing reloading of the MCM helicase.

TLS Online TPP Program

#Id: 8852

#XL - T Zoology

Geminin contains a destruction box at its N-terminus that is recognized by APC/Ccdh1, causing it to be ubiquitinylated in late anaphase and degraded by proteasomes.

TLS Online TPP Program

#Id: 8853

#XL - T Zoology

Cohesins 

The protein ring complexes that establish linkages between sister chromatids

TLS Online TPP Program

#Id: 8854

#XL - T Zoology

Cohesins establish linkages between the replicated DNA molecules, which are essential for their accurate segregation later in the cell cycle. This linking mechanism is coupled to DNA replication.