SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.

TLS Online TPP Program

#Id: 9996

#XL - T Zoology

In Wnt-Ca2+ pathway, Wnt binding to the receptor protein possibly Ryk, alone or in concert with Frizzled.

TLS Online TPP Program

#Id: 9997

#XL - T Zoology

Frizzled-G protein signaling activates PLC-beta, which cleaves PIP2 into DAG and IP3.

TLS Online TPP Program

#Id: 9998

#XL - T Zoology

Wnt/calcium pathway leads to the release of calcium stored within cells, and calcium acts as an important secondary messenger to modulate the function of many downstream targets.

TLS Online TPP Program

#Id: 9999

#XL - T Zoology

Increased Ca2+ levels activates Ca2+-dependent signaling molecules such as:

Protein kinase C, Ca2+/calmodulin-dependent protein kinase (CamKII), Calcineurin phosphatase

TLS Online TPP Program

#Id: 10000

#XL - T Zoology

Calcineurin phosphatase, dephosphorylates and activates the transcription factor, Nuclear Factor Associated with T cells (NFAT).

TLS Online TPP Program

#Id: 10001

#XL - T Zoology

Vertebrates have three homologues of the Drosophila hedgehog gene: sonic hedgehog (shh), desert hedgehog

(dhh), and indian hedgehog (ihh)