Biotrophic fungi usually penetrate the rigid cell wall via the formation of a specialized infection structure on the plant

surface called an appressorium. Then, the emerging penetration

peg breaches the rigid plant cell wall and provides entry into the plant cell. Finally, a haustorium forms upon entry into the plant cell.

TLS Online TPP Program

#Id: 9342

#XL - T Zoology

Prodomain prevents the latent TGF-β 

from binding to a cell-surface receptor.

TLS Online TPP Program

#Id: 9343

#XL - T Zoology

Prodomain forms disulfide linkages that localize the latent TGF-β to the surface of the secreting cell (GARP), to a nearby cell, or to the extracellular matrix (LTBP).

TLS Online TPP Program

#Id: 9345

#XL - T Zoology

TGF-β activation

By cytoskeletal force transmitted by integrins

TLS Online TPP Program

#Id: 9346

#XL - T Zoology

The prodomains of TGF-β1 and TGF-β3 contain a RGD motif, that allows them to bind to integrins.

TLS Online TPP Program

#Id: 9347

#XL - T Zoology

During cell migration, a tensile force is generated which physically distorts the prodomain and frees the active TGF-β dimer, initiating TGF-β signaling.

TLS Online TPP Program

#Id: 9348

#XL - T Zoology

3 separate TGF-β receptor proteins participate in binding TGF-β and activating signaling:

RI, RII, and RIII