Phosphorylation leads to a conformational change in the activation loop that unblocks kinase active site by reducing the Kd for ATP or the substrate to be phosphorylated.

TLS Online TPP Program

#Id: 10102

#XL - T Zoology

Desmosomes

Function- Strength, durability, signaling

TLS Online TPP Program

#Id: 10103

#XL - T Zoology

Hemidesmosomes

Adhesion type- Cell-matrix

Cytoskeletal attachment- Intermediate filaments

TLS Online TPP Program

#Id: 10104

#XL - T Zoology

The principal ECM adhesion receptor in epithelial hemidesmosomes is integrin α6β4.

TLS Online TPP Program

#Id: 10105

#XL - T Zoology

Hemidesmosomes

Function- Shape, rigidity, signaling

TLS Online TPP Program

#Id: 10106

#XL - T Zoology

Focal adhesions 

Adhesion type- Cell-matrix

Adhesion receptors- Integrins

Cytoskeletal attachment- Actin filaments

TLS Online TPP Program

#Id: 10107

#XL - T Zoology

Focal adhesion

Function- Shape, signaling, force transmission, cell movement