Binding of ligand to predimerized but inactive RTK alters the conformation of the dimer in such a way that the receptor’s kinase becomes activated.

TLS Online TPP Program

#Id: 8399

#XL - Q Biochemistry

The structure of the sarcomere is maintained by a number of accessory proteins: 

1. CapZ 

2.Tropomodulin

3.Titin 

4.Nebulin

TLS Online TPP Program

#Id: 8398

#XL - Q Biochemistry

In the presence of ATP and Ca+2 , the myosin heads extending from the thick

filaments walk toward the (+) ends of the thin filaments.

TLS Online TPP Program

#Id: 8397

#XL - Q Biochemistry

Z disk 

Thin actin filaments are assembled with their (+) ends embedded in a densely staining structure

TLS Online TPP Program

#Id: 8396

#XL - Q Biochemistry

Each sarcomere contains two major types of filaments: 

Thick filaments (myosin II)

Thin filaments (actin and associated proteins)

TLS Online TPP Program

#Id: 8395

#XL - Q Biochemistry

Sarcomere

Within each skeletal muscle cell are many myofibrils consisting of a repeating array of a specialized structure

TLS Online TPP Program

#Id: 8394

#XL - Q Biochemistry

When the Ca2+ levels drop:

Myosin LC is dephosphorylated by MLC phosphatase, causing muscle relaxation.