Constitutively active Ras proteins (RasD) 

Replacement of the normal glycine 12 with any other amino acid (except proline) blocks the functional binding of GAP proteins and in essence “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 10097

#XL - T Zoology

Three major classes of animal-cell junctions: 

1. Anchoring junctions

2. Tight junctions

3. Gap junctions

TLS Online TPP Program

#Id: 10098

#XL - T Zoology

Adherens junctions 

Adhesion type- Cell-cell

Principal CAMs- Cadherins

Cytoskeletal attachment- Actin filament

TLS Online TPP Program

#Id: 10099

#XL - T Zoology

Adherens junctions

functions as a tension cable that can internally brace the cell and thereby control its shape

TLS Online TPP Program

#Id: 10100

#XL - T Zoology

Desmosomes

Adhesion type- Cell-cell

Cytoskeletal attachment- Intermediate filaments

TLS Online TPP Program

#Id: 10101

#XL - T Zoology

The key CAMs in desmosomes are the desmosomal cadherins, desmoglein and desmocollin

TLS Online TPP Program

#Id: 10102

#XL - T Zoology

Desmosomes

Function- Strength, durability, signaling