Molecular Handcuff 

Phosphorylation of Raf is recognize by protein 14-3-3 dimer, which locks the autoinhibitory domain in a position where it blocks and inhibits the kinase active site

TLS Online TPP Program

#Id: 7908

#XL - Q Biochemistry

In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

TLS Online TPP Program

#Id: 9636

#XL - T Zoology

Activated RTKs and cytokine receptors to activate Ras, by two cytosolic proteins — GRB2 and Sos

TLS Online TPP Program

#Id: 8608

#XL - R Botany

There are three D cyclins in mammals:

cyclins D1, D2, and D3

TLS Online TPP Program

#Id: 10628

#XL - R Botany

From ovule to seed in gymnosperm

TLS Online TPP Program

#Id: 1352

#XL - T Zoology

GRB2 SH3 domains bind to proline-rich sequences in Sos