In humans, there are three RAS, three Raf, two MEK, and two MAP proteins.

TLS Online TPP Program

#Id: 9981

#XL - T Zoology

Delipidation process reduces Wnt signaling, creates a negative feedback mechanism for preventing excessive Wnt signaling.

TLS Online TPP Program

#Id: 9982

#XL - T Zoology

Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.

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#Id: 9983

#XL - T Zoology

TLS Online TPP Program

#Id: 9984

#XL - T Zoology

TLS Online TPP Program

#Id: 9985

#XL - T Zoology

Antagonists of Wnt:

Secreted frizzled-related protein (Sfrp)

Wnt inhibitory factor (Wif)

Dickkopf (Dkk) family

TLS Online TPP Program

#Id: 9986

#XL - T Zoology

Non-canonical Wnt signaling is initiated by the 

Wnt5a type (Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, and Wnt11).