Many RTKs and cytokine receptors specifically activate the γ isoform (PLCγ), which contains an SH2 domain.

TLS Online TPP Program

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APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

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#XL - R Botany

APC/C works with substrate-targeting factors called Cdc20 and Cdh1

TLS Online TPP Program

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#XL - R Botany

TLS Online TPP Program

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#XL - R Botany

APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module

TLS Online TPP Program

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#XL - R Botany

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]

TLS Online TPP Program

#Id: 8633

#XL - R Botany

Mutating or deleting the destruction box in mitotic cyclins prevented their ubiquitination and blocked cells from exiting mitosis.