Cyanide inhibits cytochrome c oxidase in the mitochondria, which blocks the electron transport chain.

TLS Online TPP Program

#Id: 8752

#XL - T Zoology

Predictor of Natural Disordered Regions or PONDR is one of the best available algorithms for predicting the likelihood that a given amino acid residue is in a region of intrinsic disorder, based on the surrounding amino acid sequence and amino acid composition. 

TLS Online TPP Program

#Id: 8753

#XL - T Zoology

A PONDR score of 1.0 indicates a probability of 100% that a protein will be disordered.

TLS Online TPP Program

#Id: 8754

#XL - T Zoology

The mammalian protein p53 also have both structured and unstructured segments. With its unstructured region at the carboxyl terminus four different proteins.

TLS Online TPP Program

#Id: 8755

#XL - T Zoology

Thermodynamic measurements indicate that native proteins are only marginally stable under physiological conditions. The free energy required to denature them is ∼0.4 kJ ∙ mol−1 per amino acid residue.

TLS Online TPP Program

#Id: 8756

#XL - T Zoology

Protein stability is the net balance of forces, which determine whether a protein will be in its native folded conformation or a denatured state.

TLS Online TPP Program

#Id: 8757

#XL - T Zoology

A fully folded 100-residue protein is only about 40 kJ ∙ mol−1 more stable than its unfolded form (for comparison, the energy required to break a typical hydrogen bond is ∼20 kJ ∙ mol−1).