LRR motif also found in the extracellular domain of several P/MAMP

TLS Online TPP Program

#Id: 1345

#XL - T Zoology

All Ras have the CAAX motifs at the C-terminus.

TLS Online TPP Program

#Id: 1346

#XL - T Zoology

Post-translational modifications of the CAAX motifs determine the subcellular localization and correct biological function of Ras proteins.

TLS Online TPP Program

#Id: 1347

#XL - T Zoology

SOS – Ras GEF

NF1 - Ras GAP

TLS Online TPP Program

#Id: 1348

#XL - T Zoology

RasD or RasONC  Replacement of the normal glycine 12 with any other amino acid (except proline) “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 1349

#XL - T Zoology

RAF (also known as MAPKKK),  A ser/thr protein kinase

TLS Online TPP Program

#Id: 1350

#XL - T Zoology

KSR (Kinase suppressor of Ras) is a pseudogene homolog of RAF Involve in the activation of RAF