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TLS Online TPP Program

#Id: 9871

The UVR8- COP1-SPA complex then activates the transcription of the major transcription factor HY5, which controls the expression of many of the genes induced by UV-B.

#XL - R Botany #Blue-Light Responses and Photoreceptors #Part B Pointers
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TLS Online TPP Program

#Id: 10321

#XL - Q Biochemistry

The tumor down regulates the expression of class I MHC proteins
TLS Online TPP Program

#Id: 10322

#XL - Q Biochemistry

Sometimes the tumor cells up-regulate the expression of anti-apoptotic proteins like BCL-2.
TLS Online TPP Program

#Id: 10323

#XL - Q Biochemistry
TLS Online TPP Program

#Id: 10324

#XL - Q Biochemistry

PD-1 has a structure similar to CTLA-4 and when activated negatively regulates T-cell function by inducing apoptosis of activated T cells. 
TLS Online TPP Program

#Id: 10325

#XL - Q Biochemistry

Monoclonal Antibodies Against Immune Checkpoint Molecules to Treat Cancers
TLS Online TPP Program

#Id: 10326

#XL - Q Biochemistry

Antibodies against 
CTLA-4
PD-L1 or PD-1
A CTLA-4-blocking antibody, ipilimumab