The AIM2-like receptors (ALRs) are cytosolic receptors that bind DNA molecules from bacteria and viruses.

TLS Online TPP Program

#Id: 9678

#XL - T Zoology

Activated PKB also promotes survival of many cultured cells by phosphorylating the Forkhead transcription factor FOXO3a on multiple serine and threonine residues.

TLS Online TPP Program

#Id: 9679

#XL - T Zoology

The cytosolic phosphoserine binding protein 14-3-3 then binds to phosphorylated FOXO3a and sequesters it in the cytosol.

TLS Online TPP Program

#Id: 9680

#XL - T Zoology

A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanines is constitutively active

TLS Online TPP Program

#Id: 9681

#XL - T Zoology

PI-3 kinase signaling pathway is terminated by

PTEN phosphatase, which hydrolyzes the 3-phosphate

in PI 3-phosphates.

TLS Online TPP Program

#Id: 9682

#XL - T Zoology

PTEN can remove phosphate groups attached to serine,

threonine, and tyrosine residues in proteins, its ability to

remove the 3-phosphate from PI(3,4,5)P3 is its major function in cells.

TLS Online TPP Program

#Id: 9683

#XL - T Zoology

Loss of the PTEN protein contributes to the uncontrolled growth of cells.