Inflammatory response

The response includes both localized and systemic effects, consisting of altered patterns of blood flow, an influx of phagocytic and other immune cells, removal of foreign antigens, and healing of the damaged tissue.

TLS Online TPP Program

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#XL - R Botany

Accumulation of alanine, which can be synthesized from pyruvate in one step, allosterically inhibits pyruvate kinase, slowing the production of pyruvate by glycolysis

TLS Online TPP Program

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The liver PK isozyme (L form) is regulated by glucagon

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Pyruvate Carboxylase

a mitochondrial enzyme that requires the coenzyme biotin, converts the pyruvate to oxaloacetate

TLS Online TPP Program

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The oxaloacetate is converted to PEP by phosphoenolpyruvate carboxykinase. This Mg2+ dependent reaction requires GTP as the phosphoryl group donor.

TLS Online TPP Program

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Transketolase requires the cofactor thiamine pyrophosphate (TPP)

TLS Online TPP Program

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Acetyl-CoA and NADH are potent allosteric inhibitors of the enzyme.