Viruses Employ Several Different Strategies to Evade Host Defense Mechanisms

Hepatitis C virus, inhibiting the action of PKR.

Herpes simplex virus TAP.

TLS Online TPP Program

#Id: 8325

#XL - Q Biochemistry

Critical concentration (Cc)

minimal concentration of monomers at which filaments form

TLS Online TPP Program

#Id: 8324

#XL - Q Biochemistry

The rate of addition of monomers is given by

rate constant kon (M–1 sec–1 )

The rate of loss is given by koff (sec–1)

TLS Online TPP Program

#Id: 8323

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8322

#XL - Q Biochemistry

Steady-state phase

G-actin monomers exchange with subunits at the filament ends, but there is no net change in the total length of filaments.

TLS Online TPP Program

#Id: 8321

#XL - Q Biochemistry

Elongation phase

short oligomer rapidly increases in length by the addition of actin monomers to both of its ends, causing filament elongation

TLS Online TPP Program

#Id: 8320

#XL - Q Biochemistry

The lag phase can be reduced or abolished entirely by adding premade nuclei.