#Question id: 1257
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to protein kinase A which phosphorylates multiple intracellular target proteins expressed in different cell types.
A. Inactive PKA is a tetramer consisting of two regulatory (R) subunits and two catalytic (C) subunits.
B. Each R subunit contains a pseudo-substrate domain whose sequence resembles that of a peptide substrate and binds to the active site in the catalytic domain but is not phosphorylated; thus the pseudo-substrate domain inhibits the activity of the catalytic subunits.
C. active PKA is turned off by binding of cAMP Each R subunit has two distinct cAMP-binding sites, called CNB-A and CNB-B.
D. Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; that is, binding of the first cAMP molecule to CNB-B increases the Kd for binding of the second cAMP to CNB-A. Thus small changes in the level of cytosolic cAMP can cause proportionately large changes in the number of dissociated C subunits and, hence, in cellular kinase activity.
Which of the following statements are incorrect?
#Question id: 1574
#Unit 4. Cell Communication and Cell Signaling
A bacterium entering the body through a small cut in the skin will do which of the following?
#Question id: 11661
#Unit 10. Ecological Principles
Autogenic factors results from the community and its organism for example filling in the pond by the dead organism from the pond itself. It included several other factors except____
#Question id: 23596
#Unit 1. Molecules and their Interaction Relevant to Biology
#Question id: 12390
#Unit 7. System Physiology – Animal