One of the major categories of receptors in the plasma membrane functions by forming dimers, adding phosphate groups, and then activating relay proteins. Which type does this?

#Question id: 1518

#Unit 4. Cell Communication and Cell Signaling

Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.

A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.

B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.

C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.

D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.

Which of the following statements are incorrect?

#Question id: 1263

#Unit 4. Cell Communication and Cell Signaling

The major classes of CAMs include

a. cadherins.    b. fibronectin.    c. Ig-superfamily CAMs.      d. P-selectins.

#Question id: 1264

#Unit 4. Cell Communication and Cell Signaling

 Desmosomes

#Question id: 1265

#Unit 4. Cell Communication and Cell Signaling

An example of an integrin containing cell junction is

#Question id: 1266

#Unit 4. Cell Communication and Cell Signaling

Integrins

#Question id: 1267

#Unit 4. Cell Communication and Cell Signaling

Multiple integrin forms arise from