#Question id: 13160
#Unit 4. Cell Communication and Cell Signaling
|
Column I |
Column II |
|
A. “ON” state |
i. switch I and switch II, are
bound to the terminal γ phosphate of GTP through interactions with the
backbone amide groups of conserved threonine and glycine residues. |
|
B. “OFF” state |
ii. GTPase-activating proteins |
|
|
iii. guanine nucleotide exchange
factor |
|
|
iv. Due to the removal of the γ
phosphate by GTPase-catalyzed hydrolysis causes switch I and switch II to
relax into a different conformation |
#Question id: 13159
#Unit 4. Cell Communication and Cell Signaling
#Question id: 1262
#Unit 4. Cell Communication and Cell Signaling
Although MAP kinase is often activated in multicellular animals by RTKs or cytokine receptors, signaling from other receptors can activate MAP kinase in other eukaryotic cells. we consider the mating pathway in the yeast S. cerevisiae, a well-studied example of a MAP kinase cascade linked to G protein–coupled receptors (GPCRs). Which of the following statement is incorrect?
#Question id: 1261
#Unit 4. Cell Communication and Cell Signaling
A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanine then what will be the result?
#Question id: 1260
#Unit 4. Cell Communication and Cell Signaling
Which of the following statement regarding RTK/Ras pathway is incorrect?
#Question id: 1259
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to the phosphoinositide pathway.
A. many activated RTKs and cytokine receptors initiate phosphoinositide pathway by recruiting the enzyme phosphatidylinositol-3 kinase (PI-3 kinase) to the membrane.
B. PI-3 kinase adds a phosphate to the 3′ carbon in one of two separate phosphatidylinositol substrates, leading to formation of two phosphatidylinositol 3-phosphates: PI(3,4)P2 or I(3,4,5)P3
C. PI-3 kinase pathway can trigger cell division and prevent apoptosis, thus ensuring cell survival by the activation of PKB.
D. Activated PKB phosphorylates FOXO3a, which induces the expression of several antiapoptotic genes.
Which of the following combination is correct?