Which of the following functions does the product of the p53 gene carry out?

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#Question id: 12484

#Unit 2. Cellular Organization

Match the following.

Column I	Column II
A. APC/CCdc20	i . responsible for ubiquitinating proteins, such as mitotic cyclins
B. APC/CCdh1	ii. responsible for destroying proteins, such as securin
	iii. promotes the metaphase–anaphase transition
	iv. Promotes exit from mitosis

Which of the following is correct?

TLS Online TPP Program

#Question id: 12483

#Unit 2. Cellular Organization

ATM and ATR are protein kinases that become activated following specific types of DNA damage. 

A. ATM becomes activated in response to double‐strand breaks, which are detected by the MRN protein complex. 

B. ATR becomes activated by protein‐coated ssDNA that forms when replication forks become stalled or the DNA is being repaired after various types of damage.

C. ATR phosphorylates and activates the checkpoint kinase Chk2, which phosphorylates p53. D. ATM phosphorylates and activates the checkpoint kinase Chk1, which phosphorylates and inactivates the phosphatase Cdc25.

Which of the following combination is incorrect?

TLS Online TPP Program

#Question id: 12482

#Unit 2. Cellular Organization

The Rb protein has been called the “master brake” of the cell cycle. How the Rb protein acts as a cell cycle brake?

TLS Online TPP Program

#Question id: 12481

#Unit 2. Cellular Organization

Following statements are regarding to Kinetochore-microtubule interaction in S. cerevisiae.

A. In the simple kinetochore of S. cerevisiae, a protein complex called CBF3 associates with specialized, centromere-specific form of histone H3, called CENP-A.

B. The Ndc80 complexes initially make lateral interactions with a spindle microtubule and subsequently interact with a Dam1 complex, which forms a ring around the end of the microtubule. This interaction results in an end-on attachment of the centromere to the

spindle microtubule.

C. Microtubules that “capture” kinetochores are selectively stabilized by a reduction in the rate of catastrophes, which increases the chance that the attachment will persist.

D. With the two kinetochores attached to opposite poles, the duplicated chromosome is now under tension, being pulled in both directions by the one sets of kinetochore microtubules.

Which of the following combinations is correct?

TLS Online TPP Program

#Question id: 12190

#Unit 2. Cellular Organization

CDK activity is modulated by the following proteins:

(a) cyclin, (b) CAK, (c) Wee1,  (d) p21. Following protein act as:

I. Inhibitory kinase

II. CKI Family of proteins

III. Activatory kinase

IV. Regulatory subunit

Which of the following is correct?

TLS Online TPP Program

#Question id: 12189

#Unit 2. Cellular Organization

Following statements are regarding to model for reassembly of the nuclear envelope during telophase. 

A. Extensions of the endoplasmic reticulum (ER) associate with each decondensing chromosome and then fuse with one another, forming a double membrane around the chromosome. 

B. Dephosphorylated nuclear pore subcomplexes reassemble into nuclear pores, forming individual mini-nuclei called karyomeres. 

C. The enclosed chromosome further decondenses, and subsequent fusion of the nuclear envelopes of all the karyomeres at each spindle pole forms a single nucleus containing a full set of chromosomes.

D. Phosphorylated nuclear pore subcomplexes reassemble into nuclear pores, forming individual mini-nuclei called karyomeres.

Which of the following is incorrect?