What family of proteins plays an essential role in the repression of genes that help to direct the formation of specific tissues and organs in a developing embryo?

TLS Online TPP Program

#Question id: 1107

#Unit 4. Cell Communication and Cell Signaling

Viagra causes dilation of blood vessels and increased blood flow to the penis, facilitating erection. Viagra acts by inhibiting which of the following events?

TLS Online TPP Program

#Question id: 1109

#Unit 4. Cell Communication and Cell Signaling

What role do phosphatases play in signal transduction pathways?

TLS Online TPP Program

#Question id: 1110

#Unit 4. Cell Communication and Cell Signaling

If a pharmaceutical company wished to design a drug to maintain low blood sugar levels, one approach might be to design a compound that does which of the following?

TLS Online TPP Program

#Question id: 14740

#Unit 4. Cell Communication and Cell Signaling

Rod cells sense light with the aid of a light-sensitive GPCR known as rhodopsin; choose incorrect statements

a. Rhodopsin consists of the protein opsin, which has the usual seven–transmembrane segment GPCR structure, covalently linked to a light-absorbing pigment called retinal. 

b. Rhodopsin, found only in rod cells, is localized to the thousand or so flattened membrane disks that make up the inner segment of each of these rod-shaped cells.

c. A human rod cell contains about 4 × 10⁷ molecules of rhodopsin. 

d. The heterotrimeric G protein coupled to rhodopsin, called transducin (Gt), contains a Gα unit referred to as Gαt; like rhodopsin, Gαt is found only in rod cells.

TLS Online TPP Program

#Question id: 14739

#Unit 4. Cell Communication and Cell Signaling

In heart muscle, activation series of the muscarinic acetylcholine receptor its effector K+ channel via the Gβγ subunit of a Gi protein.

a. Binding of acetylcholine triggers activation of the Gαi subunit and its dissociation from the Gβγ subunit in the usual way. 

b. The released Gβγ subunit (rather than Gαi∙GTP) binds to and opens the associated effector protein, a K+ channel. 

b. The increase in K+ permeability hyperpolarizes the membrane, which reduces the frequency of heart muscle contraction. 

d. Activation is terminated when the GTP bound to Gαi is hydrolyzed (by a GAP enzyme that is an intrinsic part of the Gαi subunit) to GDP and Gαi∙GDP recombines with Gβγ.

TLS Online TPP Program

#Question id: 14738

#Unit 4. Cell Communication and Cell Signaling

Choose correct statements about Muscarinic receptors;

a. An acetylcholine analog, In activated condition, these receptors slow the rate of heart muscle contraction.

b .This type of receptor is coupled to a Gαi protein, and ligand binding leads to the opening of an associated K+ channel.

c .The subsequent influx of K+ ions from the cytosol causes an increase in the magnitude of the usual inside-negative potential across the plasma membrane that lasts for several seconds.