TLS Online TPP Program
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TLS Online TPP Program
#Question id: 23912
#General Aptitude
A significant effect of climate change on account of global warming of terrestrial plants will be on:
TLS Online TPP Program
#Question id: 3874
#Unit 3. Fundamental Processes
A branched (“lariat”) structure is formed during:
TLS Online TPP Program
#Question id: 15009
#Unit 8. Inheritance Biology
A mutation in which most of the protein coding sequence of the gene is removed is most likely to be which type of allele?
TLS Online TPP Program
#Question id: 11149
#Unit 7. System Physiology – Animal
The Nernst equation specifies the equilibrium potential for a particular ion. This equilibrium potential is a function of ________.
TLS Online TPP Program
#Question id: 14686
#Unit 4. Cell Communication and Cell Signaling
This member of the AKAP family, designated mAKAP, anchors both PDE and the regulatory subunit of PKA to the nuclear membrane, maintaining them in a negative feedback loop that provides close local control of the ATP level and PKA activity.
B- The basal level of PDE activity in the presence of hormone (resting state) keeps cAMP levels below those necessary for PKA activation.
C- Activation of β-adrenergic receptors causes an increase in cAMP to a level in excess of that which can be degraded by PDE.
D- The resulting binding of cAMP to the R subunits of PKA releases the active catalytic (C) subunits into the cytosol. Some C subunits enter the nucleus, where they phosphorylate and thus activate certain transcription factors . Other C subunits phosphorylate PDE, stimulating its catalytic activity.
E- Active PDE hydrolyzes cAMP, thereby driving cAMP levels back to basal levels and causing re-formation of the inactive PKA C-R complex. Subsequent de-phosphorylation of PDE returns the complex to the resting state.