Following statements are regarding to regulation of S phase and mitotic cyclin levels in budding yeast.

A. In late anaphase, the anaphase-promoting complex (APC/C) ubiquitinylates S phase and mitotic cyclins.

B. In late anaphase, the anaphase-promoting complex (APC/C) phosphorylates S phase and mitotic cyclins.

C. During exit from mitosis and G1, Cdh1 is dephosphorylated and active; during S phase and mitosis, Cdh1 is phosphorylated and dissociates from APC/C, and APC/C becomes inactive.

D. During exit from mitosis and G1, Cdh1 is phosphorylated and active; during S phase and mitosis, Cdh1 is dephosphorylated and dissociates from APC/C, and APC/C becomes inactive.

E. The G1/S phase CDKs, which themselves are not APC/CCdh1 substrates, phosphorylate Cdh1 at the G1–S phase transition.

F. The G1/S phase CDKs, which themselves are not APC/CCdh1 substrates, ubiquitinylates Cdh1 at the G1–S phase transition.

Which of the following combination is correct?

#Question id: 15721

#Unit 11. Evolution and Behavior

#Question id: 4103

#Unit 3. Fundamental Processes

In a biochemical experiment, you compare the products from splicing reactions carried out in vitro using three different substrates. In each case the substrate is a construct containing a single intron surrounded by two exons, and in all cases the construct is the same overall size. But in one case, the intron is a group I intron, in another a group II intron, and in the third an intron removed by the spliceosome. Each construct is labelled in a manner that allows it to be detected after gel electrophoresis, and each is tested in two reactions—one, conditions that support self-splicing, and two, in the presence of nuclear extract as well. Note that, for simplification, only the final products of the splicing reaction are seen, but before degradation of the introns.

 Which of the following observation is/are correct?

A. In lane A, the presence of nuclear abstract, a band for the lariat and the spliced product and pre-mRNA.

B. Lane B shows Group I Introns and Lane C is for Group II introns and reaction is nonself-splicing

C. Lane C is Group I intron. Splicing takes place in the absence and presence of nuclear abstract, and the reaction is self-splicing.

#Question id: 771

#Unit 1. Molecules and their Interaction Relevant to Biology

MicroRNAs are:

P. synthesized as long pri-miRNAs;

Q. transcribed by RNA polymerase II;

R. synthesized from pre-microRNAs by an RNase III enzyme Drosha in the cytoplasm;

S. synthesized from pri-miRNAs by an enzyme Dicer in the nucleus.

#Question id: 7704

#Unit 9. Diversity of Life Forms

The best classification system is that which most closely ________.

#Question id: 1421

#Unit 4. Cell Communication and Cell Signaling

XIAP proteins: