When stress conditions arise, or when protein synthesis threatens to overwhelm the protein-folding capacity of the ER, unfolded proteins can accumulate. These conditions trigger the unfolded protein response (UPR)

a) unfolded protein response ensures to reduces the rate of protein synthesis by mTOR pathway

b) Amyloid aggregates that form before the UPR can come into play may be removed. Some are degraded by autophagy

c) Amyloid aggregates that can be removed by other mechanism such as lysosomal degradations

d)  UPR also bring the various systems into alignment by increasing the concentration of chaperones in the oxygen deprived conditions

Which of the following statements would be incorrect?

TLS Online TPP Program

#Question id: 26443

#Unit 3. Fundamental Processes

XP-V is caused by a defect in the translesion DNA polymerase

TLS Online TPP Program

#Question id: 26441

#Unit 3. Fundamental Processes

NER component and their functions are given, match them correctly

Component	Function
1. UvrA	a. DNA Pol I and DNA ligase
2. UvrB dimer	b. creates two incisions
3. UvrC	c. melts the DNA to create a single-stranded bubble around the lesion
4. DNA Pol I and DNA ligase	d. scanned Distortion

TLS Online TPP Program

#Question id: 26440

#Unit 3. Fundamental Processes

Choose the correct statement 

a. Long patch repair system is accomplished by Lig1, FEN1, Pol ζ ε, and APE1 

b. Long patch repair system is accomplished by Lig3, FEN1, Pol ξ β ,APE1 & lyase action

c. Short patch repair system is accomplished by Lig3, FEN1, Pol  ξ β,APE1 & lyase action

d. Short patch repair system is accomplished by Lig1, FEN1, Pol ζ ε, , and APE1

TLS Online TPP Program

#Question id: 26439

#Unit 3. Fundamental Processes

Which of the following Mut system involve in the rectification of oxygen damage

TLS Online TPP Program

#Question id: 26438

#Unit 3. Fundamental Processes

 Preferential removal of bases in pairs that have oxidized guanine is designed to minimize mutations using different Mut system having specific functions match them correctly

Mut system	Mutational pairing
1. MutT	a. removes G=O that is paired with C
2. MutM	b. removes A that is paired with G=O
3. MutY	c. hydrolyzes 8-oxo-dGTP

TLS Online TPP Program

#Question id: 26437

#Unit 3. Fundamental Processes

GC – TA transversion caused by the insertion of