TLS Online TPP Program

#Question id: 892


Assisted protein folding is mediated by a group of proteins known as chaperons, which of the following statements is incorrectly reperesents chaperon activity;

#Unit 1. Molecules and their Interaction Relevant to Biology
  1. chaperon help to fold, unfolded and partially folded polypeptide chains to disrupt the improper association of exposed hydrophobic segments

  2. All molecular chaperones operate by binding to an unfolded or aggregated protein’s, and molecular chaperon donot requires ATP for their activity

  3. molecular chaperones function to lift folding polypeptides out of the false minima in their folding funnels

  4. molecular chaperones were first described as heat shock proteins (Hsp) because their rate of synthesis is increased at elevated temperatures

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#Question id: 2099

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#Question id: 2102

#Unit 2. Cellular Organization

In which of the following environments would there be the greatest need for osmoregulation?

TLS Online TPP Program

#Question id: 12181

#Unit 2. Cellular Organization

Following statements are regarding to the CFTR.
A. cystic fibrosis transmembrane conductance regulator allows Cl− ions to flow out of the cell, following their concentration gradient.
B. ATP binding to CFTR’s two nucleotide-binding domains appears to close the Cl− channel, and the hydrolysis of one ATP opens it (the other ATP remains intact).
C. the CFTR channel can open only if its regulatory domain (which is unique among ABC transporters) has been phosphorylated, thus regulating the flow of ions across the membrane.
D. The maintenance of electrical neutrality requires that the Cl− ions transported by the CFTR be accompanied by positively charged ions, mainly Na+. The transported ions are osmotically accompanied by water, thus maintaining the proper level of fluidity in secretions of the airways, intestinal tract, and the ducts of the pancreas, testes, and sweat glands.
Which of the following combination is correct?