Practice Questions

  1. Home
  2. Free Resources
  3. Practice Questions
  4. 54875
TLS Online TPP Program

#Question id: 887

Polypeptides fold rapidly by a stepwise process, how does the polypeptide chain arrive at its native conformation?

#Unit 1. Molecules and their Interaction Relevant to Biology

  1. proteins appear to fold in a hierarchical manner, with small local elements of structure forming and then to yield larger elements, which coalesce with other such elements to form yet larger elements and converted into its native conformation

  2. A protein-folding pathway has been highly successful in predicting the three-dimensional structure of small proteins from their amino acid sequence atleast 156 amino acid residue that have acquired their final structure

  3. Vander waal interaction play a significant role throughout the process, as the aggregation of nonpolar amino acid side chains provides an entropic stabilization to intermediates and, eventually, to the final folded structure

  4. The native conformation of the protein folding by stepwise manner such as unfolded→transition state→molten globule→folded conformation by decreasing the free energy

More Questions
TLS Online TPP Program

#Question id: 15366

#Unit 4. Cell Communication and Cell Signaling

For pro-proliferation signaling pathways to cause uncontrolled proliferation, as is seen in cancer, this p53 up-regulation must not occur, It is therefore not surprising that p53 is inactive in most human tumors through loss of p53 function itself, down-regulation of positive regulators (PR) of p53 or up-regulation of negative regulators (NR) of p53, these regulators are accordingly
TLS Online TPP Program

#Question id: 15365

#Unit 4. Cell Communication and Cell Signaling

The MDM2 protein in its active form can form a complex with p53, inhibiting the transcription factor and causing p53 ubiquitinylation and subsequent proteasomal degradation, ATM phosphorylates MDM2 to inactivate it, causing increased stabilization of p53, but there is one another gene or key regulator which controls the level of MDM2;
TLS Online TPP Program

#Question id: 15364

#Unit 4. Cell Communication and Cell Signaling

In normal cells, FOS and MYC mRNAs and the proteins they encode are intrinsically unstable and degrade rapidly after the genes are transcribed, Conversion of the MYC proto-oncogene into an oncogene can occur by different mechanisms, Other members of this protein set include MAD, MAX, and MNT, choose incorrect statement regarding this,
TLS Online TPP Program

#Question id: 15363

#Unit 4. Cell Communication and Cell Signaling

Epithelial-to-mesenchymal transition (EMT) is thought to play a crucial role during the process of metastasis in some cancers, Snail and Twist are the two transcription factors, function as EXCEPT
TLS Online TPP Program

#Question id: 15362

#Unit 4. Cell Communication and Cell Signaling

Aflatoxin a fungal metabolite found in moldy grains, induces
TLS Online TPP Program

#Question id: 15361

#Unit 4. Cell Communication and Cell Signaling

The chemical benzo(a)pyrene, found in cigarette smoke as well as in coal tar, undergoes metabolic activation in the lungs to form a potent mutagen that mainly, causes conversion of guanine (G) to thymine (T) bases, a transversion mutation, When applied to cultured bronchial epithelial cells, activated benzo(a)pyrene induces many mutations, including inactivating mutations of the p53 gene, at codon number______