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TLS Online TPP Program

#Question id: 12836

The final layer of control that is critical in the regulation of CDKs is a family of proteins known as CDK inhibitors, or CKIs, which bind directly to the cyclin-CDK complex and inhibit its activity. Which of the following function not done by CKIs?

#Unit 2. Cellular Organization
  1. Binding of INK4s to CDK4 and CDK6 blocks their interaction with cyclin D and hence their protein kinase activity. 
  2. p27 prevents the premature activation of S phase CDKs during G1.
  3. p21CIP plays an important role in the response of metazoan cells to DNA damage by inhibiting G1/S phase CDKs and S phase CDKs, and thereby blocking entry into or passage through S phase.
  4. During ongoing DNA replication and in response to replication stress (slow DNA replication fork movement or DNA replication fork collapse), the ATR-Chk1 protein kinase cascade phosphorylates and inactivates Cdc25C, thereby preventing the activation of mitotic CDKs and inhibiting entry into mitosis.
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TLS Online TPP Program

#Question id: 5370

#Unit 8. Inheritance Biology

The pedigree below represents the inheritance of an X link recessive trait. The probability of effected child in fourth generation of family?
TLS Online TPP Program

#Question id: 5369

#Unit 8. Inheritance Biology

Above family shows inheritance of colour-blindness is recessive genetic disorder. Which of the following is correct statement? (All persons are outside of family either homozygous (female) or hemizygous (Male) are consider)
TLS Online TPP Program

#Question id: 5368

#Unit 8. Inheritance Biology

Which of the following is correct about genetic disorder in family?

A) Gene for this trait present in both sex

B) Trait is governed by mitochondrial gene

C) Sex limited trait acts like a recessive trait on an autosome

D) Sex influenced trait acts like a dominant trait on an autosome
TLS Online TPP Program

#Question id: 5367

#Unit 8. Inheritance Biology

Following pedigree showing X link recessive disorder. Which of the following confirm a carrier female in a family?
TLS Online TPP Program

#Question id: 5366

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the child in generation III will show the trait.
TLS Online TPP Program

#Question id: 5365

#Unit 8. Inheritance Biology

The following pedigree shows the inheritance of a common phenotype controlled by an autosomal recessive allele. The probability of carriers in the population is 1/3. What is the probability that a child from parents III-3 and III-4 will show the phenotype?