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TLS Online TPP Program

#Question id: 12836

The final layer of control that is critical in the regulation of CDKs is a family of proteins known as CDK inhibitors, or CKIs, which bind directly to the cyclin-CDK complex and inhibit its activity. Which of the following function not done by CKIs?

#Unit 2. Cellular Organization
  1. Binding of INK4s to CDK4 and CDK6 blocks their interaction with cyclin D and hence their protein kinase activity. 
  2. p27 prevents the premature activation of S phase CDKs during G1.
  3. p21CIP plays an important role in the response of metazoan cells to DNA damage by inhibiting G1/S phase CDKs and S phase CDKs, and thereby blocking entry into or passage through S phase.
  4. During ongoing DNA replication and in response to replication stress (slow DNA replication fork movement or DNA replication fork collapse), the ATR-Chk1 protein kinase cascade phosphorylates and inactivates Cdc25C, thereby preventing the activation of mitotic CDKs and inhibiting entry into mitosis.
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TLS Online TPP Program

#Question id: 10930

#Unit 7. System Physiology – Animal

A 34-year-old man with schizophrenia has had chronic fatigue for 6 months. He has a good appetite, but has refused to eat vegetables for 1 year because he hears voices saying that vegetables are poisoned. His physical and neurological examinations are normal. His hemoglobin level is 9.1 g/dL, leukocyte count is 10,000/μl3, and MCV is 122. Which of the following is the most likely diagnosis?
TLS Online TPP Program

#Question id: 10932

#Unit 7. System Physiology – Animal

A 62-year-old man complains of headaches, visual difficulties, and chest pains. His examination shows a red complexion and a large spleen. His complete blood count follows: hematocrit, 58%, WBC 13,300/μl, and platelets 600,000/μl. His arterial oxygen saturation is 97% on room air. Which of the following would you recommend as a treatment?
TLS Online TPP Program

#Question id: 10938

#Unit 7. System Physiology – Animal

A 45-year-old woman developed fatigue in July and had blood counts that were reported to be normal. She was hospitalized because of a very severe headache in December, and was found to have a blood pressure of 175/90. Her laboratory values were as follows: hemoglobin (8.3 g/dL), RBC count (2.2 × 10^6/μl), Hct (23%), MCV (89 fL), WBCs (5100/μl), platelets (262 × 10^3/μl), and reticulocyte count 0.8%. What is the diagnosis for this patient?
TLS Online TPP Program

#Question id: 10940

#Unit 7. System Physiology – Animal

Adhesion of white blood cells to the endothelium is
TLS Online TPP Program

#Question id: 10941

#Unit 7. System Physiology – Animal

In a normal healthy person, which of the following blood components has the shortest life span?
TLS Online TPP Program

#Question id: 10942

#Unit 7. System Physiology – Animal

A 45-year-old man presents to the emergency room with a 2-week history of diarrhea that has gotten progressively worse over the last several days. He has minimal urine output and is admitted to the hospital for dehydration. His stool specimen is positive for parasitic eggs. Which type of WBCs would have an elevated number?