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TLS Online TPP Program

#Question id: 12835

Following statements are regarding to the surveillance mechanism. Which of the following statement is incorrect?

#Unit 2. Cellular Organization
  1. DNA damage leads to the activation of p21, a transcription factor that induces the expression of the gene encoding the CDK inhibitor p53.
  2. When the DNA damage occurs during S phase or in G2, Cdc25C inhibition by Chk1/2 results in the inhibition of mitotic CDKs and hence arrest in G2.
  3. Cells sense DNA replication stress that results in stalling or slowing of replication forks. Such stress triggers activation of the ATR-Chk1 checkpoint pathway and results in downregulation of S phase CDK activity and prevents the firing of late-replicating origins.
  4. ATM halts cell cycle progression by Chk2-mediated inhibition of Cdc25, thus preventing activation of CDKs. This inhibition can occur in G1 or G2.
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TLS Online TPP Program

#Question id: 5371

#Unit 8. Inheritance Biology

The trait represented in the following pedigree (shaded symbols) is known to be inherited as a single dominant gene. Calculate the probability of the trait appearing in the offspring if the first cousins should marry and have children.
TLS Online TPP Program

#Question id: 5370

#Unit 8. Inheritance Biology

The pedigree below represents the inheritance of an X link recessive trait. The probability of effected child in fourth generation of family?
TLS Online TPP Program

#Question id: 5369

#Unit 8. Inheritance Biology

Above family shows inheritance of colour-blindness is recessive genetic disorder. Which of the following is correct statement? (All persons are outside of family either homozygous (female) or hemizygous (Male) are consider)
TLS Online TPP Program

#Question id: 5368

#Unit 8. Inheritance Biology

Which of the following is correct about genetic disorder in family?

A) Gene for this trait present in both sex

B) Trait is governed by mitochondrial gene

C) Sex limited trait acts like a recessive trait on an autosome

D) Sex influenced trait acts like a dominant trait on an autosome
TLS Online TPP Program

#Question id: 5367

#Unit 8. Inheritance Biology

Following pedigree showing X link recessive disorder. Which of the following confirm a carrier female in a family?
TLS Online TPP Program

#Question id: 5366

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the child in generation III will show the trait.