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#Question id: 12186


In 2001, the Nobel Prize in Physiology or Medicine was awarded to three cell cycle scientists. Paul Nurse was recognized for his studies with the fission yeast S. pombe, in particular for the discovery and characterization of the wee1+ gene. What did the characterization of the wee1+ gene tell us about cell cycle control?

#Unit 2. Cellular Organization
  1. The dual-specificity protein kinase Wee1 phosphorylates CDKs on the activatory tyrosine 15.
  2. Yeast cells with a defective wee1+ gene activate S phase CDKs prematurely and hence experience premature entry into DNA replication. 
  3. Fission yeast cells carrying a CDK1 mutation in which the tyrosine 15 residue is replaced by phenylalanine (which is structurally similar to tyrosine but cannot be phosphorylated) show the premature mitotic CDK activation and entry into mitosis.
  4. The dual-specificity protein phosphatase Wee1 dephosphorylates CDKs on the inhibitory tyrosine 15.

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#Question id: 5716

#Unit 8. Inheritance Biology

Which of the meiotic pairing possibilities in tetraploids and their consequence is correct?

A-chromosomes pair as bivalents, segregate normally producing diploid gametes.

B- Chromosomes pair as quadrivalent, segregates normally producing tetraploid gametes.

C-Chromosome pair as Trivalents form, segregation leads to nonfunctional aneuploid gametes

 D- Chromosome pair as Trivalents form, segregation leads to producing diploid gametes

TLS Online TPP Program

#Question id: 5715

#Unit 8. Inheritance Biology

Following some abnormality is due to Gene rearrangement on chromosome. 

A, Affecting the expression of gene

B. Disrupt the function of gene

C. Reduced recombination between gene present in inverted region

D. Cross over suppressor 

Which of the following above abnormality is may be associated with inversion?

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#Question id: 5714

#Unit 8. Inheritance Biology

Homologous chromosomes pair in prophase I as a following way, if crossing over occur between P and Q gene of homologous chromosome?

Which of the following consequence of above abnormality?

A. Dicentric chromosome visible at anaphase I

B. Results in formation of acentric chromatid

C. Recombinant gamete unable to produced viable progeny due to missing of many gene

D. Resulting recombinant gamete become aneuploid 

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#Question id: 5713

#Unit 8. Inheritance Biology

Following some statement are correct?

A) Translocation may be associated with movement of genetic material within the same chromosome

B) A person that is heterozygous for translocation may result in non viability in their zygote

C)  A person that is heterozygous for inversion may result in non viability in their recombinant zygote

D) A person that is heterozygous for translocation and lack of crossing over within translocated area result in all viable gametes

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#Question id: 5712

#Unit 8. Inheritance Biology

In each of the following cases, determine the consequences of a single crossover within the inverted region of a pair of homologous chromosomes with the gene order A B C D in one chromosome and a c b d in the other. There is a two situation of centromere for that gene. 

(A) Centromere is not included within the inversion.

(B) Centromere is included within the inversion

Following consequence are resulting are

I - The crossover chromatids consist of a dicentric and an acentric

II- One Cross over product is duplicated for the terminal region contain in A and deficient for the terminal region containing D

III- Both cross over products is monocentric

Following is correct combination for consequence?

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#Question id: 5711

#Unit 8. Inheritance Biology

Which of the following is results of Crossing over?