During ubiquitin-mediated protein degradation in various events of cell cycle, ubiquitin-protein ligases ubiquitinylate substrate proteins, marking them for degradation by proteasomes. Cyclins are degraded through the action of two different ubiquitin-protein ligases, SCF and the anaphase-promoting complex or cyclosome. Following statements are regarding to SCF and APC/C.

A. SCF controls the G1–S phase transition by degrading G1/S phase cyclins and, CDK inhibitory proteins.

B. APC/C degrades S phase and mitotic cyclins, thereby promoting the exit from mitosis.

C. SCF and APC/C are multi-subunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin protein ligases.

D. SCF and APC/C belong to the different ubiquitin-protein ligase family, their regulation is same.

E. SCF recognizes its substrates only when they are phosphorylated.

F. SCF and APC/C both recognizes its substrates only when they are phosphorylated.

Which of the following is incorrect?

TLS Online TPP Program

#Question id: 23437

#Unit 1. Molecules and their Interaction Relevant to Biology

Veena who is the sister-in-law of Ashok, is the daughter-in-law of Kalyani. Dheeraj is the father of Sudeep who is the only brother of Ashok. How Kalyani is related to Ashok?

TLS Online TPP Program

#Question id: 23436

#Unit 1. Molecules and their Interaction Relevant to Biology

Pointing a photograph X said to his friend Y , “She is the only daughter of the father of my mother.” How X is related to the person of photograph?

TLS Online TPP Program

#Question id: 23435

#Unit 1. Molecules and their Interaction Relevant to Biology

Deepak said to Nitin, “That boy playing with the football is the younger of the two brothers of the daughter of my father’s wife.” How is the boy playing football related to Deepak?

TLS Online TPP Program

#Question id: 23440

#Unit 1. Molecules and their Interaction Relevant to Biology

You are playing football in a park. When you kick the ball, it strikes and breaks the window pane of a nearby house. You would:

TLS Online TPP Program

#Question id: 23441

#Unit 1. Molecules and their Interaction Relevant to Biology

If in the examination hall, you find that the question paper is too tough to be answered satisfactorily by you, the best thing to do for you is to

TLS Online TPP Program

#Question id: 23442

#Unit 1. Molecules and their Interaction Relevant to Biology

You are returning home from school. On the way, you find a sealed envelope in a street, fully addressed with unused stamps on it You would: