The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

#Question id: 387

#Unit 1. Molecules and their Interaction Relevant to Biology

For a weak acid with a pKa of 6.0, What would be the ratio of acid to salt at pH 5.

#Question id: 389

#Unit 1. Molecules and their Interaction Relevant to Biology

A weak acid HA has a pKa of 5.0.  If 1.0 mol of this acid and 0.1 mol of NaOH were dissolved in one liter of water, what would the final pH be?

#Question id: 390

#Unit 1. Molecules and their Interaction Relevant to Biology

What are the properties arising due to varying concentrations of solute in a given solvent, irrespective of the nature of solute with respect to the solvent?

#Question id: 391

#Unit 1. Molecules and their Interaction Relevant to Biology

In a hospital laboratory, a 10.0 mL sample of gastric juice, obtained several hours after a meal, was titrated with 0.1 M NaOH to neutrality; 7.2 mL of NaOH was required. The patient’s stomach contained no ingested food or drink, thus assume that no buffers were present. What was the pH of the gastric juice?

#Question id: 393

#Unit 1. Molecules and their Interaction Relevant to Biology

Carbon dioxide (CO2) is readily soluble in water, according to the equation CO2 + H2O ↔ H2CO3. Carbonic acid (H2CO3) is a weak acid. If CO2 is bubbled into a beaker containing pure, freshly distilled water, which of the following graphs correctly describes the results?

#Question id: 400

#Unit 1. Molecules and their Interaction Relevant to Biology

Consider two solutions: solution X has a pH of 4; solution Y has a pH of 7. From this information, we can reasonably conclude that ________.