The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

#Question id: 5077

#Unit 5. Developmental Biology

Humans and mice heterozygous for loss-of-function mutations in Pax6 have:

#Question id: 826

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one is incorrect about the proteins with segments rich in Pro (P), Glu (E), Ser (S), and Thr (T), the so-called PEST proteins,

#Question id: 15197

#Unit 8. Inheritance Biology

In the following pedigree shows the segregation of two different recessive traits.

Assuming that both traits are 10 cM apart on the X chromosome, what is the probability that a male child will have both recessive traits?

#Question id: 20318

#Unit 4. Cell Communication and Cell Signaling

#Question id: 3420

#Unit 11. Evolution and Behavior

Following are key points about the effect of genetic drift:

A. Genetic drift is significant in small populations.

B. Genetic drift can cause allele frequencies to change in a pre-directed way.

C. Genetic drift can lead to a loss of genetic variation within populations.

D. Genetic drift can cause harmful alleles to become fixed.

Which one of the following combination of the above statements are true?