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TLS Online TPP Program

#Question id: 4118

If the 5’ splice site sequence changed from 5’- GUAAGU-3’ to 5’-GUAUGU-3’, predict the effect of the sequence change on U1 binding and U6 snRNP binding in an in vitro protein– RNA binding assay.

#Unit 3. Fundamental Processes

  1. The mutation will not change binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  2. The mutation will likely cause an increase in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

  3. The mutation will likely cause a decrease in binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  4. The mutation will likely cause a decrease in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

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TLS Online TPP Program

#Question id: 5369

#Unit 8. Inheritance Biology

Above family shows inheritance of colour-blindness is recessive genetic disorder. Which of the following is correct statement? (All persons are outside of family either homozygous (female) or hemizygous (Male) are consider)
TLS Online TPP Program

#Question id: 5368

#Unit 8. Inheritance Biology

Which of the following is correct about genetic disorder in family?

A) Gene for this trait present in both sex

B) Trait is governed by mitochondrial gene

C) Sex limited trait acts like a recessive trait on an autosome

D) Sex influenced trait acts like a dominant trait on an autosome
TLS Online TPP Program

#Question id: 5367

#Unit 8. Inheritance Biology

Following pedigree showing X link recessive disorder. Which of the following confirm a carrier female in a family?
TLS Online TPP Program

#Question id: 5366

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the child in generation III will show the trait.
TLS Online TPP Program

#Question id: 5365

#Unit 8. Inheritance Biology

The following pedigree shows the inheritance of a common phenotype controlled by an autosomal recessive allele. The probability of carriers in the population is 1/3. What is the probability that a child from parents III-3 and III-4 will show the phenotype?
TLS Online TPP Program

#Question id: 5364

#Unit 8. Inheritance Biology

The inheritance of a given disorder is recorded in families shown below: Based on the above limited information, which one of the following inheritance patterns of disorder was not shown in the family?