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TLS Online TPP Program

#Question id: 4118

If the 5’ splice site sequence changed from 5’- GUAAGU-3’ to 5’-GUAUGU-3’, predict the effect of the sequence change on U1 binding and U6 snRNP binding in an in vitro protein– RNA binding assay.

#Unit 3. Fundamental Processes

  1. The mutation will not change binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  2. The mutation will likely cause an increase in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

  3. The mutation will likely cause a decrease in binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  4. The mutation will likely cause a decrease in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

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TLS Online TPP Program

#Question id: 11071

#Unit 7. System Physiology – Animal

At the end of inhalation, with an open glottis, the pleural pressure is
TLS Online TPP Program

#Question id: 11072

#Unit 7. System Physiology – Animal

The following diagram shows pulmonary airway resistance expressed as a function of pulmonary volume. Which relationship best describes the normal lung?
TLS Online TPP Program

#Question id: 11075

#Unit 7. System Physiology – Animal

A 65-year-old man with emphysema due to 34 years of cigarette smoking is admitted to hospital due to dyspnea. With further tests the mean pulmonary arterial pressure is determined to be 45 mm Hg at rest. He is hypoxic (PO2 = 49 mm Hg), hypercapnic (85 mm Hg), and slightly acidotic. The cardiovascular and oxygen changes are due to which of the following?
TLS Online TPP Program

#Question id: 11076

#Unit 7. System Physiology – Animal

Which of the following will decrease pulmonary blood flow resistance?
TLS Online TPP Program

#Question id: 11077

#Unit 7. System Physiology – Animal

A person’s normal tidal volume is 400 ml with a dead space of 100 ml. The respiratory rate is 12 breaths/min. The person is placed on ventilator for surgery and the tidal volume is 700 with a rate of 12. What is the approximate alveolar Pco2 for this person?
TLS Online TPP Program

#Question id: 11079

#Unit 7. System Physiology – Animal

The diffusing capacity of a gas is the volume of gas that will diffuse through a membrane each minute for a pressure difference of 1 mm Hg. Which of the following gases is often used to estimate the oxygen diffusing capacity of the lungs?