TLS Online TPP Program

#Question id: 4118


If the 5’ splice site sequence changed from 5’- GUAAGU-3’ to 5’-GUAUGU-3’, predict the effect of the sequence change on U1 binding and U6 snRNP binding in an in vitro protein– RNA binding assay.

#Unit 3. Fundamental Processes
  1. The mutation will not change binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  2. The mutation will likely cause an increase in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

  3. The mutation will likely cause a decrease in binding of U1 and on other hand this will likely enhance binding of the U6 snRNP with the 5’ splice site

  4. The mutation will likely cause a decrease in binding of U1 and on other hand this will not change binding of the U6 snRNP with the 5’ splice site

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TLS Online TPP Program

#Question id: 11940

#Unit 7. System Physiology – Animal

Which of the following is filtered most readily by the glomerular capillaries?

TLS Online TPP Program

#Question id: 11941

#Unit 7. System Physiology – Animal

Under conditions of normal renal function, which of the following is true of the concentration of urea in tubular fluid at the end of the proximal tubule?

TLS Online TPP Program

#Question id: 11942

#Unit 7. System Physiology – Animal

A patient’s urine is collected for 2 hr, and the total volume is 600 ml during this time. Her urine osmolarity is 150 mOsm/L, and her plasma osmolarity is 300 mOsm/L. What is her “free water clearance”?

TLS Online TPP Program

#Question id: 11944

#Unit 7. System Physiology – Animal

The maximum clearance rate possible for a substance that is totally cleared from the plasma is equal to which of the following?

TLS Online TPP Program

#Question id: 11945

#Unit 7. System Physiology – Animal

A patient has the following laboratory values: arterial pH = 7.13, plasma HCO3− = 15 mEq/L, plasma chloride concentration = 118 mEq/L, arterial Pco2 = 28 mm Hg, and plasma Na+ concentration = 141 mEq/L. What is the most likely cause of his acidosis?

TLS Online TPP Program

#Question id: 12070

#Unit 7. System Physiology – Animal

A 26-year-old man develops glomerulonephritis, and his GFR decreases by 50% and remains at that level. For which of the following substances would you expect to find the greatest increase in plasma concentration?