Which of the following proteins prevents eukaryotic mRNAs from being recruited to the ribosome prior to egg fertilization

#Question id: 23471

#General Aptitude

#Question id: 16956

#Unit 4. Cell Communication and Cell Signaling

#Question id: 12747

#Unit 13. Methods in Biology

#Question id: 1255

#Unit 4. Cell Communication and Cell Signaling

Following statements are regarding to the mechanism of action of cholera toxin.

A. cholera toxin is a homodimeric protein, target G proteins, interfering with normal signaling in host cells.

B. cholera toxin associates with a small G protein, known as ARF6.

C. association with ARF6 activates cholera toxin, which catalyzes the transfer of ADP-ribose from NAD+ to the critical Arg residue in the P loop of the alpha subunit of Gs.

D. ADP-ribosylation blocks the GEF activity of Gs and thereby renders Gs permanently inactive.

E. This results in continuous activation of the adenylyl cyclase of intestinal epithelial cells, chronically high cAMP, and active PKA dephosphorylates the CFTR Cl- channel and a sodium-proton exchanger in the intestinal epithelial cells.

Which of the following combination is correct?

#Question id: 15785

#Unit 5. Developmental Biology