Following statements are regarding to the mechanism of action of cholera toxin.

A. cholera toxin is a homodimeric protein, target G proteins, interfering with normal signaling in host cells.

B. cholera toxin associates with a small G protein, known as ARF6.

C. association with ARF6 activates cholera toxin, which catalyzes the transfer of ADP-ribose from NAD+ to the critical Arg residue in the P loop of the alpha subunit of Gs.

D. ADP-ribosylation blocks the GEF activity of Gs and thereby renders Gs permanently inactive.

E. This results in continuous activation of the adenylyl cyclase of intestinal epithelial cells, chronically high cAMP, and active PKA dephosphorylates the CFTR Cl- channel and a sodium-proton exchanger in the intestinal epithelial cells.

Which of the following combination is correct?

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#Question id: 5450

#Unit 8. Inheritance Biology

Which of these definitions of heritability is most correct?

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#Question id: 5751

#Unit 8. Inheritance Biology

A biochemical mutant that must be supplied with a particular nutrient for growth would be described as a(n)

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#Question id: 5346

#Unit 8. Inheritance Biology

The following typical pedigree illustrates the key point that affected children are born to unaffected parents: Which of the following is correct statement?

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#Question id: 13144

#Unit 8. Inheritance Biology

Shell coiling of the snail Limnaea peregra(genetic maternal effect)  the shell coils (s+s+) which is termed dextral coiling, while some snails exhibiting sinistral coiling (ss). The allele for dextral (s +) is dominant over the allele for sinistral (s). If a male homozygous for dextral alleles (s+s+) is crossed with a female homozygous for sinistral alleles (ss) all of the F1 are heterozygous (s+s) and have a sinistral shell. If these F1 snails are self-fertilized, what is the phenotype of the F2 snail?

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#Question id: 12169

#Unit 8. Inheritance Biology

During the phenotypic variations, the genotype shows variation at different effect given in graph;

According to the graph , this is an example of,

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#Question id: 12168

#Unit 8. Inheritance Biology

The proportion of the total phenotypic  variation that is due to genetic differences is known as