Few mutants (column A) and their results (column B) are listed in the table given below:

Column A	Column B
A. Gain-of-function of Ski	I. Inhibits the ability of activated type I TGF-β receptors (RI) to phosphorylate R-Smad proteins
B. Loss-of-function of RII receptor	II. Transcription activation induced by TGF-β and mediated by Smad complexes is shut down
C. Gain-of-function of smad-7
D. Loss-of-function of R-smad

Match the correct mutation with the observe result?

#Question id: 621

#Unit 1. Molecules and their Interaction Relevant to Biology

Michaelis and Menten assumed that the overall reaction for an enzyme-catalyzed reaction could be written as Using this reaction, the rate of breakdown of the enzyme-substrate complex can be described by the expression:

#Question id: 620

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statements about a plot of V0 vs. [S] for an enzyme that follows Michaelis-Menten kinetics is false?

#Question id: 619

#Unit 1. Molecules and their Interaction Relevant to Biology

The benefit of measuring the initial rate of a reaction V0 is that at the beginning of a reaction:

#Question id: 618

#Unit 1. Molecules and their Interaction Relevant to Biology

 In the following diagram of the first step in the reaction catalyzed by the protease chymotrypsin, the process of general base catalysis is illustrated by the number ________, and the process of covalent catalysis is illustrated by the number _________.

#Question id: 617

#Unit 1. Molecules and their Interaction Relevant to Biology

Compare the two reaction coordinate diagrams below and select the answer that correctly describes their relationship.  In each case, the single intermediate is the ES complex.

#Question id: 616

#Unit 1. Molecules and their Interaction Relevant to Biology

Which equilibrium below applies to noncompetitive inhibition?