TLS Online TPP Program

#Question id: 15366


For pro-proliferation signaling pathways to cause uncontrolled proliferation, as is seen in cancer, this p53 up-regulation must not occur, It is therefore not surprising that p53 is inactive in most human tumors through loss of p53 function itself, down-regulation of positive regulators (PR) of p53 or up-regulation of negative regulators (NR) of p53, these regulators are accordingly

#Unit 4. Cell Communication and Cell Signaling
  1. PR-p14ARF, NR-MDM2
  2. PR- MDM2, NR- p14ARF
  3. PR-P15INK4b, NR-Chk2
  4. PR- p14ARF, NR-ATM