Practice Questions

TLS Online TPP Program

#Question id: 1528

Mutation of p53 is described as a dominant-negative mutation. Which of the following statement is correct regarding to the mechanism by which this mutation causes the dominant-negative phenotype?

#Unit 4. Cell Communication and Cell Signaling

Mutation of p53 is a dominant-negative mutation because the active protein is a dimer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.
Mutation of p53 is a dominant-negative mutation because the active protein is a pentamer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.
Mutation of p53 is a dominant-negative mutation because the active protein is a tetramer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.
Mutation of p53 is a dominant-negative mutation because the active protein is a heptamer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.