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TLS Online TPP Program

#Question id: 1525

Following statements are regarding to chromatin remodelling factors SWI/SNF complexes. Which one of them is incorrect?

#Unit 4. Cell Communication and Cell Signaling

  1. SWI/SNF complexes large and diverse multiprotein complexes, which have an ATP-dependent helicase at their core, often control histone modification and chromatin remodeling.

  2. SWI/SNF complexes can cause changes in the positions or structures of nucleosomes, making genes accessible or inaccessible to DNA-binding proteins that control transcription.

  3. SWI/SNF plays a role in repressing the expression of E2F genes, thereby inhibiting progression through the cell cycle.

  4. Loss of SWI/SNF function, just like gain of Rb function, can lead to overgrowth and tumor formation.

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TLS Online TPP Program

#Question id: 12215

#Unit 7. System Physiology – Animal

Damage to the gastric mucosal barrier is a forerunner of gastric ulcer. Which of the following can both damage the gastric mucosal barrier and stimulate gastric acid secretion?
TLS Online TPP Program

#Question id: 12214

#Unit 7. System Physiology – Animal

A 53-year-old man with a recurrent history of ulcer disease associated with diarrhea and a strong family history of duodenal ulcer disease is suspected of having Zollinger-Ellison syndrome (gastrinoma). Secretin (2 units/kg) was given as a rapid intravenous injection to test for gastrinoma. Which of the following results would support the existence of gastrinoma following secretin administration?
TLS Online TPP Program

#Question id: 12213

#Unit 7. System Physiology – Animal

The gastric phase of gastric secretion accounts for about 60% of the acid response to a meal. Which of the following can virtually eliminate the secretion of acid during the gastric phase?
TLS Online TPP Program

#Question id: 12212

#Unit 7. System Physiology – Animal

 A 71-year-old man with upper abdominal pain and blood in the stool takes NSAIDS for the pain and washes it down with whiskey. Pentagastrin administration produced lower than predicted levels of gastric acid secretion. Secretion of which of the following substances is most likely to be diminished in this patient with gastritis?
TLS Online TPP Program

#Question id: 12211

#Unit 7. System Physiology – Animal

A 57-year-old man is admitted as an emergency for upper GI bleeding. Endoscopy reveals multiple ulcers in the duodenum. Serum gastrin levels are eight-fold higher compared to normal. Zollinger-Ellison syndrome (ZES, gastrinoma) is suspected. Administration of which of the following substances is useful in confirming the diagnosis?
TLS Online TPP Program

#Question id: 12062

#Unit 7. System Physiology – Animal

Mass movements are often stimulated after a meal by distention of the stomach (gastrocolic reflex) and distention of the duodenum (duodenocolic reflex). Mass movements often lead to which of the following?