Tumor-suppressor genes generally encode proteins that in one way or another inhibit cell proliferation. Loss-of-function mutations in one or more of these proliferation inhibitory proteins contribute to the development of many cancers. Prominent among the classes of proteins encoded by tumor-suppressor genes are:

A. Intracellular proteins that regulate or inhibit entry into the cell cycle

B. Receptors or signal transducers for secreted hormones or developmental signals that inhibit cell proliferation

C. Checkpoint pathway proteins that arrest the cell cycle if DNA is damaged

D. Proteins that promote apoptosis

Following genes belongs to the above class-

i. p53

ii. Rb

iii.TGF- β

iv. Caspase 3 and 7

which of the following match is correct?

#Question id: 4808

#Unit 8. Inheritance Biology

When F1 female Drosophila of the genotype AaBbCc is test crossed, ( Gene A and B located at 10 map unit in transe configuration but gene C are independently assort for both gene. Which of the following test cross progeny that is that is more frequent?

#Question id: 4810

#Unit 8. Inheritance Biology

In a haploid organism, the C and D loci are 8 m.u. apart. From a cross C d X c D, which of the following proportion following progeny classes: (a) C D; (b) c d; (c) C d

#Question id: 4811

#Unit 8. Inheritance Biology

Three incompletely link gene as a B-A-C order. A cross allowed between AAbbcc X aaBBCC produce f1 progeny allowed test cross. Which of the following offspring is a result of double cross over?

#Question id: 4812

#Unit 8. Inheritance Biology

Two character X and Y ,both follow law of dominance due to 3:1 F2 phenotypic ratio monohybrid cross separately If carry out dihybrid selfing cross for heterozygous genotype for both character does not follow law of independence assortment in normal environmental condition due to?

#Question id: 4813

#Unit 8. Inheritance Biology

You perform the three different two-factor crosses (Cross 1: XY and xy, Cross 2: YZ and yz, and Cross 3: XZ and xz). Assume all crosses are between diploid flies homozygous for the alleles of these genes. You observe 7% recombinants in the first cross, 20% recombinants in the second cross, and 13% recombinants in the third cross. if cross between XyZ and xYz leads to which of the followining recombinant with double cross over .

#Question id: 4814

#Unit 8. Inheritance Biology

The frequency of recombinant gametes is half the frequency of crossing over between genes present on same chromosome is due to