we examine how the deregulation of growth-promoting and growth-inhibiting signaling pathways contributes to tumorigenesis. Mutations-

A. A mutation that alters a single amino acid (valine to glutamine) in the transmembrane region of the HER2 receptor

B. A deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor Results-

i. dimerization of the receptor, even in the absence of the normal EGF-related ligand, transforming it into the oncoprotein, a constitutively active kinase

ii. to constitutive activation of the kinase activity of the resulting oncoprotein

iii. no dimerization, even in the presence of the normal EGF-related ligand, repression of kinase activity

which of the following results are displayed after these mutations?

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#Question id: 1047

#Unit 4. Cell Communication and Cell Signaling

A virion is a(n)

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#Question id: 3896

#Unit 3. Fundamental Processes

Which one of the following is not involved in steroid hormone action?

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#Question id: 10548

#Unit 6. System Physiology – Plant

flg22-elicited response is dependent on the presence of the LRR receptor-like kinase, what will be the causes of mutant form of LRR receptor-like kinase FLS2?

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#Question id: 11453

#Unit 7. System Physiology – Animal

Which type of receptor would you expect to be most abundant in the antennae of a moth?

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#Question id: 10996

#Unit 7. System Physiology – Animal

A ventricular depolarization wave when traveling 60° in the frontal plane will cause a large positive deflection in which of the following leads?