Following statements are regarding to cortical granule reaction.

A. To initiating the slow block to polyspermy the release of Ca2+ that occurs when the sperm enters the egg is critical for activating the egg’s metabolism and initiating development

B. Calcium ions release the inhibitors from maternally stored messages, allowing these mRNAs to be translated

C. Calcium ions are not release the inhibition of nuclear division, thereby allowing cleavage to occur.

D. Udx1, the enzyme responsible for the reduction of oxygen to crosslink the fertilization envelope, is also NADPH-dependent

E. The fertilization envelope is elevated from the cell membrane by glycosaminoglycans which provides support for the blastomeres during cleavage

Which of the following combinations are correct?

#Question id: 2983

#Unit 2. Cellular Organization

Cell cycle is regulated by master regulators (cyclin and CDKs). In vertebrates, G1 CDK activity rises during G1 and is stimulated by the presence of growth factors. When signaling from growth factors is sustained, the resulting cyclin D–CDK4/6 complexes begin phosphorylating Rb, releasing some E2F, which stimulates transcription of the genes encoding cyclin E, CDK2, and E2F itself. In a particular cell type there is a mutation in Rb such that it cannot be phosphorylated. What will be the correct expression pattern of cyclin E in these cells after mitotic stimulation?

#Question id: 2982

#Unit 2. Cellular Organization

Match the following proteins (Column I) with their functions (Column II) during cell cycle.

#Question id: 2981

#Unit 2. Cellular Organization

For the nuclear envelope to be broken down as cells go from prophase to prometaphase during mitosis, the nuclear lamina has to be disassembled. Which of the following statement is incorrect?

#Question id: 2980

#Unit 2. Cellular Organization

Following statements are regarding to the protein phosphatase Cdc14 function in budding yeast.

A. In budding yeast, the protein phosphatase Cdc14 throws the switch between two mutually antagonistic states during anaphase.

B. Cdc14 is kept inactive during most of the cell cycle, but is activated during anaphase by a GTPase signaling pathway known as the mitotic exit network.

C. Mitotic exit network is unresponsive to spindle position and becomes active in anaphase.

D. Cdc14 phosphatase activated by the activation of protein kinase cascade.

E. Cdc14 dephosphorylates APC/CCdh1 and Sic1 to promote mitotic cyclin degradation

and mitotic CDK inactivation, respectively. This process leads to exit from mitosis.

Which of the following combination is incorrect?

#Question id: 2979

#Unit 2. Cellular Organization

Use the data in the accompanying table to answer the question. Minutes Spent in Cell Cycle Phases-

#Question id: 2978

#Unit 2. Cellular Organization

The most important regulatory control that restricts cyclins to the appropriate cell cycle stage is ubiquitin mediated, proteasome-dependent protein degradation. Which of the following statement is incorrect regarding to the degradation of protein?