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TLS Online TPP Program

#Question id: 5654

Two human disorders, Prader-Willi syndrome and Angelman syndrome, occur when a small deletion in a specific region of chromosome 15 is contributed by either the father or mother, respectively. Why does this small deletion not behave as a recessive allele for either syndrome, that is, why is its loss not made up for by the good copy of the region on chromosome 15 contributed by the other parent?

#Unit 5. Developmental Biology

  1. This portion of chromosome 15 is invariably mutated, so the other parent contributes recessive alleles that are thus homozygous and perturb development.

  2. The copy of chromosome 15 from the other parent has genes in the region of the deletion that are imprinted, and thus inactive; in the absence of any active copies of these genes, development cannot proceed normally.

  3. The genes in this portion of chromosome 15 are special in that they are required in two copies for normal development, and so the loss of one set does not allow normal development.

  4. Chromosomes with deletions do not go through mitosis correctly, so cell divisions in the embryo result in cells with abnormal numbers of chromosomes, and these cells do not contribute properly to the development of the organism.

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TLS Online TPP Program

#Question id: 23347

#Unit 1. Molecules and their Interaction Relevant to Biology

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TLS Online TPP Program

#Question id: 23346

#Unit 1. Molecules and their Interaction Relevant to Biology

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TLS Online TPP Program

#Question id: 23345

#Unit 1. Molecules and their Interaction Relevant to Biology

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TLS Online TPP Program

#Question id: 24165

#Unit 1. Molecules and their Interaction Relevant to Biology

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TLS Online TPP Program

#Question id: 24164

#Unit 1. Molecules and their Interaction Relevant to Biology

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TLS Online TPP Program

#Question id: 24163

#Unit 1. Molecules and their Interaction Relevant to Biology

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