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#Question id: 5654


Two human disorders, Prader-Willi syndrome and Angelman syndrome, occur when a small deletion in a specific region of chromosome 15 is contributed by either the father or mother, respectively. Why does this small deletion not behave as a recessive allele for either syndrome, that is, why is its loss not made up for by the good copy of the region on chromosome 15 contributed by the other parent?

#Unit 5. Developmental Biology
  1. This portion of chromosome 15 is invariably mutated, so the other parent contributes recessive alleles that are thus homozygous and perturb development.

  2. The copy of chromosome 15 from the other parent has genes in the region of the deletion that are imprinted, and thus inactive; in the absence of any active copies of these genes, development cannot proceed normally.

  3. The genes in this portion of chromosome 15 are special in that they are required in two copies for normal development, and so the loss of one set does not allow normal development.

  4. Chromosomes with deletions do not go through mitosis correctly, so cell divisions in the embryo result in cells with abnormal numbers of chromosomes, and these cells do not contribute properly to the development of the organism.

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TLS Online TPP Program

#Question id: 11112

#Unit 7. System Physiology – Animal

The respiratory movement representing the total amount of exchangeable air is the:

TLS Online TPP Program

#Question id: 11111

#Unit 7. System Physiology – Animal

Hypoventilation dramatically increases carbonic acid concentration and involves:

TLS Online TPP Program

#Question id: 11089

#Unit 7. System Physiology – Animal

A 45-year-old man inhaled as much air as possible and then expired with a maximum effort until no more air could be expired. This produced the maximum expiratory flow-volume curve shown in the following diagram. What is the forced vital capacity of this man (in liters)?


TLS Online TPP Program

#Question id: 11088

#Unit 7. System Physiology – Animal

At a fraternity party a 17-year-old male places a paper bag over his mouth and breathes in and out of the bag. As he continues to breathe into this bag, his rate of breathing continues to increase. Which of the following is responsible for the increased ventilation?

TLS Online TPP Program

#Question id: 11087

#Unit 7. System Physiology – Animal

Which of the following oxygen-hemoglobin dissociation curves corresponds to normal blood (red line) and blood containing carbon monoxide (green line)?

TLS Online TPP Program

#Question id: 11086

#Unit 7. System Physiology – Animal

A 17-year-old female was bicycling without a helmet when she fell and hit her head. In the emergency room, she was not conscious and was receiving ventilator assistance. Her blood gases follow:

PaO2 = 52 mm Hg,

PaCO2 = 75 mm Hg, pH = 7.15, and

HCO3− = 31 mM

The majority of the CO2 was being transported as