TLS Online TPP Program

#Question id: 7273


Hox9 and Hox10 paralogues specify the stylopod, Hox11 paralogues specify the zeugopod, and Hox12 and Hox13 paralogues specify the autopod. This scenario has been confirmed by numerous experiments.

Which of the following experiment correctly describe this scenario?

#Unit 5. Developmental Biology
  1. If knocked out all six alleles of the three Hox10 paralogues (Hox10aaccdd) in mouse embryos, the resulting mice not only had severe axial skeletal defects, they also had no femur or patella they did have humerus.
  2. When all six alleles of the three Hox11 paralogues were knocked out, the resulting hindlimbs had tibias-fibulas but neither femur nor humerus.
  3. knocking out all the paralogous Hoxa9 and Hoxd12 loci resulted in loss of the autopod.
  4. If knocked out all six alleles of the three Hox10 and Hox11 paralogues (Hox10aaccdd) in mouse embryos, the resulting mice have no limb.