#Question id: 1241
#Unit 4. Cell Communication and Cell Signaling
Which of the following is a common step in the opening/closing of ion channels by acetylcholine and rhodopsin binding to their receptors?
#Question id: 1239
#Unit 4. Cell Communication and Cell Signaling
GTPases serve in many signal transduction pathways and the presence of GTP or GDP dictates whether the pathway is on or off, respectively. Which of the following statements is TRUE regarding guanine nucleotide exchange factors (GEF) and the role in these signaling pathways?
#Question id: 1238
#Unit 4. Cell Communication and Cell Signaling
Which of the following can lead to loss-of-heterozygosity in a tumor-suppressor gene?
a. deletion of the normal copy
b. non dysjunction during mitosis
c. somatic mutation of the normal copy
d. mitotic recombination between a wild-type and mutant allele
#Question id: 1237
#Unit 4. Cell Communication and Cell Signaling
Arrange the following events in the proper order in which they occur during transduction of the Notch/Delta signaling pathway:
a. cleavage of Notch by TACE
b. binding of Delta to Notch
c. translocation of Notch segment to the nucleus
d. interaction of Notch with transcription factors
e. cleavage of Notch by Presenilin 1
#Question id: 1236
#Unit 4. Cell Communication and Cell Signaling
Arrange the following events in the proper order in which they occur during transduction of the TNF-α signal
a. phosphorylation of I-κB
b. binding of E3 ubiquitin ligase to I-κB
c. polyubiquitination of I-κB
d. nuclear localization of NF-κB
e. activation of TAK1 kinase
#Question id: 1235
#Unit 4. Cell Communication and Cell Signaling
Arrange the following events in the proper order in which they occur during transduction of the EGF signal:
a. transphosphorylation of the EGF receptor
b. dissociation of GDP from Ras
c. dissociation of Ras from Sos
d. binding of GRB2 to the EGF receptor
e. binding of GTP to Ras