#Question id: 15306
#Unit 4. Cell Communication and Cell Signaling
The transformation of a normal cell to a cancer cell is accompanied by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;
Gene |
Primary tumor |
Proposed function |
i) APC |
Colorectal |
Binds β
‐catenin acting as transcription factor |
ii) BRCA1 |
Breast |
DNA repair |
iii) MSH2, MLH1 |
Melanoma, pancreatic |
p16: Cdk inhibitor ARF: stabilizes p53 |
iv) E‐Cadherin |
Breast, colon |
Cell adhesion molecule |
v) INK4a |
Colorectal |
Mismatch repair |
vi) NF1 |
Neurofibromas |
Activates GTPase of Ras |
Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions; |
#Question id: 11666
#Unit 7. System Physiology – Animal
The osmoregulatory process called secretion refers to the ________.
#Question id: 15389
#Unit 8. Inheritance Biology
#Question id: 12198
#Unit 6. System Physiology – Plant
#Question id: 19366
#Unit 13. Methods in Biology