A 24-year-old African-American man comes to the emergency room 3 hr after the onset of severe back and chest pain. These problems started while he was skiing. He lives in Los Angeles and had a previous episode of these symptoms 5 years ago while visiting Wyoming. He is in obvious pain. Laboratory studies show the following:

Hemoglobin                                        11 gm/dl

Leukocyte count                                 22,000/μl3

Reticulocyte count                              25%

What is the diagnosis of this patient?

#Question id: 1402

#Unit 4. Cell Communication and Cell Signaling

Which of the following oncoproteins possess(es) protein kinase activity?

#Question id: 1403

#Unit 4. Cell Communication and Cell Signaling

Tumor-suppressor genes encode proteins with which of the following functions?

a. growth-promoting               b. growth-arresting                  c. pro-apoptotic

d. anti-apoptotic                      e. DNA repair

#Question id: 1404

#Unit 4. Cell Communication and Cell Signaling

Which of the following are transcription factors?

#Question id: 1405

#Unit 4. Cell Communication and Cell Signaling

A gain-of-function mutation in which of the following would have the same effect as a gain-of-function mutation in Ras?

#Question id: 1406

#Unit 4. Cell Communication and Cell Signaling

Which of the following is a consequence of p53 stabilization?

a. stabilization of Cdc25A      b. activation of ATM                c. blocked apoptosis

d. transcription of p21                        e. DNA repair

#Question id: 1407

#Unit 4. Cell Communication and Cell Signaling

Which of the following is pro-apoptotic?

a. Bax              b. Bcl-2                       c. p53              d. protein kinase B      e. PTEN